Rozprawa doktorska Promotor: prof dr hab med. Janusz Marcinkiewicz

Pobieranie 233.23 Kb.
Rozmiar233.23 Kb.
1   2   3   4   5   6   7   8   9   10   11

9. Abstract

Taurine is a sulfonic β-amino acid of a significant regulatory role in human organism – it is necessary for proper development of central nervous system as well as for function of reproductive and immune system. Numerous observations indicate its particular importance for proper function of granulocytes. Studies performed over last 10 years have demonstrated that taurine haloamines (chloramine – TauCl – and bromamine – TauBr), synthesized in inflammatory reaction by activated neutrophils and eosinophils, show in vitro considerable immunoregulatory and antibacterial properties. Application of TauCl in topical treatment of infections (mostly in ophthalmology and laryngology) is presently studied in phase II clinical trials.

The aim of this work was to investigate and compare these properties of both compounds, which may give reasons for possible therapeutic application of TauBr in acute inflammatory conditions.

Stability of TauCl and TauBr in acellular environment, at various conditions of pH and temperature has been investigated. Cytotoxicity of both compounds has been studied and maximum non-cytotoxic concentrations determined, both for in vitro cell cultures and in vivo application at the site of acute inflammation. An attempt has been made to determine the mechanism of TauCl transport across the cellular membrane. Influence of TauCl and TauBr in vitro on production of cytokines and nitric oxide by inflammatory cells has been studied. Influence of both compounds on acute inflammatory reaction in vivo has been investigated.

Both studied taurine derivatives show significant effect in acute inflammatory reaction; TauBr as compared to TauCl is characterized by weaker anti-inflammatory properties and stronger antibacterial action. This observation as well as greater stability of TauCl indicates that TauCl is a more promising compound as related to clinical application.

10. Bibliografia

  1. Aderem A, Underhill DM: Mechanisms of phagocytosis in macrophages. Annu Rev Immunol. 1999; 17: 593-623.

  2. Aruoma OI, Halliwell B, Hoey BM, Butler J: The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J. 1988; 256: 251-255.

  3. Babior BM: Oxygen dependent microbial killing by phagocytes. Engl J Med 1978; 298: 659-68.

  4. Banks MA, Porter DW, Martin WG, Castranova V: Taurine protects against oxidant injury to rat alveolar pneumocytes. Adv Exp Med Biol. 1992; 315: 341-354.

  5. Barua M, Liu Y, Quinn MR: Taurine chloramine inhibits inducible nitric oxide synthase and TNF-alpha gene expression in activated alveolar macrophages: decreased NF-kappaB activation and IkappaB kinase activity. J Immunol. 2001 Aug 15; 167(4): 2275-81.

  6. Bitoun M, Tappaz M: Gene expression of taurine transporter and taurine biosynthetic enzymes in hyperosmotic states. In: Della Corte eds. Taurine 4, Plenum Press, NY 2000; 483: 239.

  7. Cantin AM: Taurine modulation of hypochlorous acid-induced lung epithelial cell injury in vitro. Role of anion transport. J Clin Invest. 1994 Feb; 93(2): 606-14.

  8. Chesney RW, Gusowski N, Dabbagh S: Renal cortex taurine content regulates renal adaptive response to altered dietary intake of sulfur amino acid. J Clin Chem 1985; 76: 2213-21.

  9. Chiarla C, Giovannini I, Siegel JH, Boldrini G, Castagneto M: The relationship between plasma taurine and other amino acid levels in human sepsis. J Nutr. 2000 Sep; 130(9): 2222-7.

  10. Chorazy M, Kontny E, Marcinkiewicz J, Maslinski W: Taurine chloramine modulates cytokine production by human peripheral blood mononuclear cells. Amino Acids. 2002; 23(4): 407-13.

  11. Chorazy-Massalska M, Kontny E, Kornatka A, Rell-Bakalarska M, Marcinkiewicz J, Maslinski W.: The effect of taurine chloramine on pro-inflammatory cytokine production by peripheral blood mononuclear cells isolated from rheumatoid arthritis and osteoarthritis patients. Clin Exp Rheumatol. 2004 Nov-Dec; 22(6): 692-8.

  12. Claesson R, Karlsson M, Zhang Y, Carlsson J: Relative role of chloramines, hypochlorous acid, and proteases in the activation of human polymorphonuclear leukocyte collagenase. J Leukoc Biol. 1996; 60: 598-602.

  13. Davies JM, Horwitz DA, Davies KJ: Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis. Free Radic Biol Med. 1993; 15: 637 643.

  14. Emerson DK, McCormick ML, Schmidt JA, Knudson CM: Taurine monochloramine activates a cell death pathway involving Bax and Caspase-9. J Biol Chem. 2005 Feb 4; 280(5): 3233-41.

  15. Englert RP, Shacter E: Distinct modes of cell death induced by different reactive oxygen species: amino acyl chloramines mediate hypochlorous acid-induced apoptosis. J Biol Chem. 2002 Jun 7; 277(23): 20518-26.

  16. Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Brennan ML, Lusis AJ, Belaaouaj A, Hotchkiss RS, Heinecke JW: Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proc Natl Acad Sci USA. 2001 Oct 9; 98(21): 11961-6.

  17. Gordon RE, Shaked AA, Solano DF: Taurine protects hamster bronchioles from acute NO2-induced alterations. Am J Pathol. 1986 Dec; 125(3): 585-600.

  18. Gottardi W, Nagl M: Chemical properties of N-chlorotaurine sodium, a key compound in the human defence system. Arch Pharm (Weinheim). 2002 Nov; 335(9): 411-21.

  19. Gottardi W, Hagleitner M, Nagl M.: N,N-dichlorotaurine: chemical and bactericidal properties. Arch Pharm (Weinheim). 2005 Oct; 338(10): 473-83.

  20. Grisham MB, Jefferson MM, Melton DF, Thomas EL: Chlorination of endogenous amines by isolated neutrophils. Ammonia- dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines. J Biol Chem. 1984; 259: 10404-10413.

  21. Grisham MB, Gaginella TS, von Ritter C, Tamai H, Be RM, Granger DN: Effects of neutrophil-derived oxidants on intestinal permeability, electrolyte transport, and epithelial cell viability. Inflammation. 1990 Oct; 14(5): 531-42.

  22. Hagar HH: The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Toxicol Lett. 2004 Jul 15; 151(2): 335-43.

  23. Hampton MB, Kettle AJ, Winterbourn CC. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 1998; 92: 3007-17.

  24. Henderson JP, Byun J, Williams MV, Mueller DM, McCormick ML, Heinecke JW: Production of brominating intermediates by myeloperoxidase. J Biol Chem. 2001; 275: 7867-75.

  25. Idrissi AE, Trenkner E: Taurine as a modulator of excitatory and inhibitory neurotransmission. Neurochem Res. 2004 Jan; 29(1): 189-97.

  26. Jong EC, Henderson WR, Klebanoff SJ: Bactericidal activity of eosinophil peroxidase. J Immunol. 1980 Mar; 124(3): 1378-82.

  27. Kanayama A, Inoue J, Sugita-Konishi Y, Shimizu M, Miyamoto Y: Oxidation of Ikappa Balpha at methionine 45 is one cause of taurine chloramine-induced inhibition of NF-kappa B activation. J Biol Chem. 2002; 277: 24049-56

  28. Kim C, Park E, Quinn MR, Schuller-Levis G: The production of superoxide anion and nitric oxide by cultured murine leukocytes and the accumulation of TNF-alpha in the conditioned media is inhibited by taurine chloramine. Immunopharmacology. 1996 Sep; 34(2-3): 89-95.

  29. Kim JW, Kim C: Inhibition of LPS-induced NO production by taurine chloramine in macrophages is mediated though Ras-ERK-NF-kappaB. Biochem Pharmacol. 2005 Sep 15; [Epub ahead of print]

  30. Klamt F, Shacter E: Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage. J Biol Chem. 2005 Jun 3; 280(22): 21346-52.

  31. Klebanoff SJ, Hamon CB: Role of myeloperoxidase mediated antimicrobial system in intact leukocytes. J Reticuloendothel Soc. 1992; 12: 170-5.

  32. Kontny E, Szczepanska K, Kowalczewski J, Kurowska M, Janicka I, Marcinkiewicz J, Maslinski W: The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheum. 2000 Oct; 43(10): 2169-77.

  33. Kontny E, Rudnicka W, Kowalczewski J, Marcinkiewicz J, Maslinski W: Selective inhibition of cyclooxygenase 2-generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine. Arthritis Rheum. 2003 Jun; 48(6): 1551-5.

  34. Koprowski M, Marcinkiewicz J: Taurine chloramine – its role in immunity and new perspectives for clinical use. Centr Eur J Immunol. 2002; 27(2): 69-74

  35. Kwasny-Krochin B, Bobek M, Kontny E, Gluszko P, Biedron R, Chain BM, Maslinski W, Marcinkiewicz J: Effect of taurine chloramine, the product of activated neutrophils, on the development of collagen-induced arthritis in DBA 1/J mice. Amino Acids. 2002; 23(4): 419-26.

  36. Learn DB, Fried VA, Thomas EL: Taurine and hypotaurine content of human leukocytes. J Leukoc Biol. 1990; 48: 174-182.

  37. Liu Y, Quinn MR: Chemokine production by rat alveolar macrophages is inhibited by taurine chloramine. Immunol Lett. 2002 Jan 1; 80(1): 27-32.

  38. Liu Y, Barua M, Serban V, Quinn MR: Production of inflammatory mediators by activated C6 cells is attenuated by taurine chloramine inhibition of NF-kappaB activation. Adv Exp Med Biol. 2003; 526: 365-72.

  39. Mahalakshmi K, Pushpakiran G, Anuradha CV: Taurine prevents acrylonitrile-induced oxidative stress in rat brain. Pol J Pharmacol. 2003 Nov-Dec; 55(6): 1037-43.

  40. Marcinkiewicz J, Grabowska A, Bereta J, Stelmaszynska T: Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generation of nitric oxide and other macrophage inflammatory mediators. J Leukoc Biol. 1995; 58: 667-74.

  41. Marcinkiewicz J: Neutrophil chloramines: missing links between innate and acquired immunity. Immunol Today. 1997; 18: 577-580.

  42. Marcinkiewicz J, Grabowska A, Bereta J, Bryniarski K, Nowak B: Taurine chloramine down-regulates the generation of murine neutrophil inflammatory mediators. Immunopharmacology. 1998; 40: 27-38.

  43. Marcinkiewicz J, Nowak B, Grabowska A, Bobek M, Petrovska L, Chain B: Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase-halide system. Immunology. 1999 Nov; 98(3): 371-8.

  44. Marcinkiewicz J, Mak M, Bobek M, Biedron R, Bialecka A, Koprowski M, Kontny E, Maslinski W: Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide. Inflamm Res. 2005 Jan; 54(1): 42-9.

  45. Marquez LA, Dunford HB: Chlorination of taurine by myeloperoxidase. Kinetic evidence for an enzyme-bound intermediate. J Biol Chem. 1994; 269: 7950-6.

  46. Mayeno AN, Curran AJ, Roberts RL, Foote CS: Eosinophils preferentially use bromide to generate halogenating agents. J Biol Chem. 1989 Apr 5; 264(10): 5660-8.

  47. McLoughlin DM, Stapleton PP, Bloomfield FJ: Influence of taurine and a substituted taurine on the respiratory burst pathway in the inflammatory response. Biochem Soc Trans. 1991; 19: 73 78.

  48. Midwinter RG, Peskin AV, Vissers MC, Winterbourn CC: Extracellular oxidation by taurine chloramine activates ERK via the epidermal growth factor receptor. J Biol Chem. 2004 Jul 30; 279(31): 32205-11.

  49. Nagl M, Hess MW, Pfaller K, Hengster P, Gottardi W: Bactericidal activity of micromolar N chlorotaurine: evidence for its antimicrobial function in the human defense system. Animicrob Agents Chemother 2000a; 44: 2507-13.

  50. Nagl M, Teuchner B, Pottinger E et al.: Tolerance of N-chlorotaurine, a new antimicrobial agent, in infectious conjunctivitis - a phase II pilot study. Ophthalmologica. 2000b; 214: 111-4.

  51. Neher A, Nagl M, Appenroth E et al.: Acute otitis externa: efficacy and tolerability of N chlorotaurine, a novel endogenous antiseptic agent. Laryngoscope. 2004; 114(5): 850-4.

  52. Neher A, Fischer H, Appenroth E, Lass-Florl C, Mayr A, Gschwendtner A, Ulmer H, Gotwald TF, Gstottner M, Kozlov V, Nagl M: Tolerability of N-chlorotaurine in chronic rhinosinusitis applied via yamik catheter. Auris Nasus Larynx. 2005 Jul 21; [Epub ahead of print]

  53. Olszanecki R, Marcinkiewicz J: Taurine chloramine and taurine bromamine induce heme oxygenase-1 in resting and LPS-stimulated J774.2 macrophages. Amino Acids. 2004 Aug; 27(1): 29-35.

  54. Olszowska E, Olszowski S, Zgliczynski JM, Stelmaszynska T: Enhancement of proteinase-mediated degradation of proteins modified by chlorination. Int.J.Biochem. 1989; 21: 799-805.

  55. Park E, Quinn MR, Wright CE, Schuller-Levis G: Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells. J Leukoc Biol. 1993; 54: 119-24.

  56. Park E, Schuller-Levis G, Quinn MR: Taurine chloramine inhibits production of nitric oxide and TNF-alpha in activated RAW 264.7 cells by mechanisms that involve transcriptional and translational events. J Immunol 1995; 154: 4778-84

  57. Park E, Schuller-Levis G, Jia JH, Quinn MR. Preactivation exposure of RAW 264.7 cells to taurine chloramines attenuates subsequent production of nitric oxide and expression of iNOS mRNA. J Leukoc Biol. 1997; 61: 161-6.

  58. Park E, Jia J, Quinn MR, Schuller-Levis G: Taurine chloramine inhibits lymphocyte proliferation and decreases cytokine production in activated human leukocytes. Clin Immunol. 2002 Feb; 102(2): 179-84.

  59. Pelletier M, Roberge CJ, Gauthier M, Vandal K, Tessier PA, Girard D: Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo. J Leukoc Biol. 2001 Sep; 70(3): 367-73.

  60. Peskin AV, Midwinter RG, Harwood DT, Winterbourn CC: Chlorine transfer between glycine, taurine, and histamine: reaction rates and impact on cellular reactivity. Free Radic Biol Med. 2005 Feb 1; 38(3): 397-405.

  61. Quinn MR, Park E, Schuller-Levis G: Taurine chloramine inhibits prostaglandin E2 production in activated RAW 264.7 cells by post-transcriptional effects on inducible cyclooxygenase expression. Immunol Lett. 1996 May; 50(3): 185-8.

  62. Quinn MR, Barua M, Liu Y, Serban V: Taurine chloramine inhibits production of inflammatory mediators and iNOS gene expression in alveolar macrophages; a tale of two pathways: part I, NF-kappaB signaling. Adv Exp Med Biol. 2003; 526: 341-8.

  63. Quinn MR, Liu Y, Barua M, Serban V: Taurine chloramine inhibits production of inflammatory mediators and iNOS gene expression in alveolar macrophages; a tale of two pathways: part II, IFN-gamma signaling through JAK/Stat. Adv Exp Med Biol. 2003; 526: 349-56.

  64. Shasby DM, Hampson F: Effects of chlorinated amines on endothelial and epithelial barriers in vitro and ex vivo. Exp Lung Res. 1989 May; 15(3): 345-57.

  65. Schuller-Levis G, Mehta PD, Rudelli R, Sturman J: Immunologic consequences of taurine deficiency in cats. J Leukoc Biol. 1990 Apr; 47(4): 321-31.

  66. Schuller-Levis G, Quinn MR, Wright C, Park E: Taurine protects against oxidant-induced lung injury: possible mechanism(s) of action. Adv Exp Med Biol. 1994; 359: 31-9.

  67. Schuller-Levis GB, Park E: Taurine: new implications for an old amino acid. FEMS Microbiol Lett. 2003 Sep 26; 226(2): 195-202.

  68. Serban V, Liu Y, Quinn MR: Production of nitric oxide by activated microglial cells is inhibited by taurine chloramine. Adv Exp Med Biol. 2003; 526: 357-64.

  69. Sturman JA: Taurine in development. Physiol Rev. 1993 Jan; 73(1): 119-47.

  70. Tappaz ML: Taurine biosynthetic enzymes and taurine transporter: molecular identification and regulations. Neurochem Res. 2004 Jan; 29(1): 83-96.

  71. Tatsumi T, Fliss H: Hypochlorous acid and chloramines increase endothelial permeability: possible involvement of cellular zinc. Am J Physiol. 1994 Oct; 267(4 Pt 2): H1597 607.

  72. Teuchner B, Nagl M, Schidlbauer A, Ishiko H, Dragosits E, Ulmer H, Aoki K, Ohno S, Mizuki N, Gottardi W, Larcher C: Tolerability and efficacy of N-chlorotaurine in epidemic keratoconjunctivitis--a double-blind, randomized, phase-2 clinical trial. J Ocul Pharmacol Ther. 2005 Apr; 21(2): 157-65.

  73. Thomas EL: Myeloperoxidase, hydrogen peroxide, chloride antimicrobial system: effect of exogenous system on antibacterial action against Escherichia coli. Infect Immun. 1979; 25: 110 4.

  74. Thomas EL, Grisham MB, Jefferson MM: Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils. J Clin Invest. 1983; 72: 441-454.

  75. Thomas EL, Grisham MB, Jefferson MM: Preparation and characterization of chloramines. Meth Enzymol. 1986; 132: 569-71.

  76. Thomas EL, Bozeman PM, Jefferson MM, King CC: Oxidation of bromide by the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase. Formation of bromamines. J Biol Chem. 1995 Feb 17; 270(7): 2906-13.

  77. van Dalen CJ, Kettle AJ: Substrates and products of eosinophil peroxidase. Biochem J. 2001 Aug 15; 358(Pt 1): 233-9.

  78. Verdrengh M, Tarkowski A: Inhibition of septic arthritis by local administration of taurine chloramine, a product of activated neutrophils. J Rheumatol. 2005 Aug; 32(8): 1513-7.

  79. Vile GF, Rothwell LA, Kettle AJ: Initiation of rapid, P53-dependent growth arrest in cultured human skin fibroblasts by reactive chlorine species. Arch Biochem Biophys. 2000 May 1; 377(1): 122-8.

  80. Vinton NE, Laidlaw SA, Ament ME, Kopple JD: Taurine concentrations in plasma and blood cells of patients undergoing long-term parenteral nutrition. Am J Clin Nutr. 1986 Sep; 44(3): 398-404.

  81. Vissers MC, Carr AC, Chapman AL: Comparison of human red cell lysis by hypochlorous and hypobromous acids: insights into the mechanism of lysis. Biochem J. 1998 Feb 15; 330 (Pt 1):131-8.

  82. Vissers MC, Pullar JM, Hampton MB: Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochem J. 1999 Dec 1; 344 Pt 2: 443-9.

  83. Weiss SJ, Klein R, Slivka A, Wie M: Chlorination of taurine by human neutrophils: evidence for hypochlorous acid generation. J Clin Invest. 1982; 70: 598-603.

  84. Winterbourn CC, Vissers MC, Kettle AJ: Myeloperoxidase. Curr Opin Hematol. 2000 Jan; 7(1): 53-8.

  85. Wojtecka-Lukasik E, Marton A, Krajewska K, Burakowski T, Gujski M, Maslinska D, Maslinski S: Taurine chloramine modifies carrageenin- and casein-induced inflammation in the rat. Inflamm Res. 2004 Mar; 53 Suppl 1: S23-4.

  86. Wojtecka-Lukasik E, Gujski M, Roguska K, Maslinska D, Maslinski S: Taurine chloramine modifies adjuvant arthritis in rats. Inflamm Res. 2005 Apr; 54 Suppl 1: S21-2.

  87. Wright CE, Tallan HH, Lin YY, Gaull GE: Taurine: biological update. Annu Rev Biochem. 1986; 55: 427-453.

  88. Yazdanbakhsh M, Eckmann CM, Roos D: Killing of schistosomula by taurine chloramine and taurine bromamine. Am.J.Trop.Med.Hyg. 1987; 37: 106-110.

  89. Zgliczynski JM, Stelmaszynska T: Chlorinating ability of human phagocytosing leucocytes. Eur J Biochem. 1975 Aug 1;56(1):157-62.

  90. Zhang M, Izumi I, Kagamimori S, Sokejima S, Yamagami T, Liu Z, Qi B: Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino Acids. 2004 Mar; 26(2): 203-7.

: Content
Content -> Punktacja uczniów kl. 1-3
Content -> Dane osobowe
Content -> Tworzenie aplikacji mobilnych do monitoringu środowiska nowa specjalność magisterska w języku angielskim
Content -> SzczegóŁowy opis tematu zamówienia
Content -> Port Lotniczy im. Mikołaja Kopernika we Wrocławiu Wroclaw Nicolaus Copernicus Airport Rozkład lotów lato 2012 Flight schedule summer 2012
Content -> Port Lotniczy im. Mikołaja Kopernika we Wrocławiu
Content -> 14 nowych wariantów rolek do zaginania taśm transportowych od igus
Content -> SzczegóŁowy opis zamówienia
Content -> Abc posługi pasterskiej dla kapłana opiekuna/pasterza Wspólnoty ze Szkoły Nowej Ewangelizacji (sne)
Content -> SzczegóŁowy opis przedmiotu zamówienia prowadzonego w trybie przetargu nieograniczonego nr bzp/PN/160/2014

1   2   3   4   5   6   7   8   9   10   11

© 2019
wyślij wiadomość

    Strona główna